Pediatrics

This review discusses the significance of the FDA-approved drug inotuzumab ozogamicin in pediatric patients with acute lymphocytic leukemia (ALL) and relapsed/refractory (R/R) ALL, and the evolving therapeutic options in R/R ALL.

Patients aged 7 years and older can now be treated for their cataplexy or excessive daytime sleepiness with the extended-release oral formulation.

The increase was observed across multiple subgroups, including those with overweight or obesity and hospitalized patients.

Oral immunotherapy is a growing area of research that involves ingesting increasing doses of the allergen to desensitize the patient’s immune system.

Although the findings indicate a potential for predicting asthma or wheezing onset, these trends cannot yet be used for early diagnoses in individual children.

Video chatting, texting, watching videos, and playing video games were activities most commonly associated with depressive symptoms in adolescents.

Significant polarization surrounding COVID-19 vaccinations in late 2020 and early 2021 looked to have had an impact in increasing vaccine hesitancy.

Research showed that children born via assisted reproductive technology were 36% more likely to develop heart defects.

By utilizing a lower dose, patients can avoid potential adverse events and high financial burden.

Pharmacists and health care providers can counsel around vitamin D supplements and natural intake to increase a child’s vitamin D consumption.

The findings support current recommendations for pregnant individuals or those who might become pregnant during the influenza season, specifically those with successive pregnancies.

Treatment for primary coenzyme Q10 (CoQ10) deficiency can include high-dose oral CoQ10 supplementation, but not all patients respond to this treatment.

A recent study found that indoor allergen exposure, including mouse and cockroach allergens, led to an increased risk of respiratory viral infections in children with asthma.

MDL-101 is a proposed novel precision medicine that targets the LAMA1 gene, causing LAMA2 congenital muscular dystrophy type 1a.

The guidelines mark a shift in practice by recommending a multimodal approach to opioid prescribing practices.

Investigators found a significant association for febrile seizures, but not with epilepsy.

Treatment is typically tailored to the individuals, with HCT being the only curative treatment bone marrow failure, but long-term outcomes are generally poorer due to toxicities.

Investigators reported that more than half of individuals had great knowledge about protecting themselves from COVID-19.

Further trials are required to examine the long-term feasibility of intravenous immunoglobulin (IVIG) for multisystem inflammatory syndrome.

The authors urge that screening, prevention, and treatment of anxiety and depression should be important health care priorities for youth who have chronic pain.

NS-050/NCNP-03 is being developed to aid individuals with confirmed gene mutations that are treatable with exon 50 skipping therapy.

Surprisingly, those with overweight BMI at diagnosis did not have a poor prognosis.

Pediatric patients weighing 20 kg to <50 kg should take 20 mg of apremilast twice daily and children weighing at least 50 kg should take 30 mg twice daily.

Pharmacists can help caregivers by recommending a healthy balanced diet containing high vitamin D intake and supplementation when needed.

Remind parents that routine exams, immunizations, and nutrition are crucial to helping children succeed.

The commencement of the phase 1 clinical trial of SAT-3247 is expected in Q3 of 2024.

The FDA also granted rare pediatric disease designation for the drug.

Immunization rates have not returned to pre-pandemic levels, leaving millions of children and infants at risk for measles or diphtheria, tetanus, and pertussis.

The approval marks the first oral immunotherapy treatment to mitigate allergic reactions, including anaphylaxis.