Brain Health

Use of antidepressants and other classes of prescription drugs can increase the risk of driving impairment compared to nonuse, so clinicians and pharmacists should review these risks with older adults.

“There is method to this madness” describes routines that affect adherence to medication regimens.

Investigators said that these results were promising, indicating that trigonelline could help to alleviate cognitive decline associated with aging.

Maintaining a purpose in life has the potential to reduce apathy related to dementia and cognitive decline.

In clinical trials, lecanemab showed a reduction of amyloid beta plaque in patients with Alzheimer disease.

Testosterone may protect the brain against dementia pathology, but the association has not been proven.

Infections were associated with a 1.49-fold increase in the rate of dementia in both the short- and long-term rates, however, the increases were greater in the short term.

Symptoms of dementia can be difficult to differentiate from typical age-related behavior changes and other common and potentially curable conditions.

Failing to protect the elderly from disease has consequences beyond nursing homes.

In addition to improving risk evaluation in older adults at home, point-of-care testing may help clinicians manage patients with dementia who cannot communicate and those living in depopulated areas.

Heart health may influence long-term brain health as early as middle age.

This social determinant of health could have the same level of negative impact on health as the experience of racism, poverty, or low education.

The recent discovery could aid further research on the cause of Huntington’s disease and other inherited conditions.

UB-311 has shown to be well-tolerated with a durable antibody response in a previous phase 1 trial, and new results from a phase 2a study support its continued development.

Investigators aimed to determine whether liraglutide, an anti-obesity medication, could impact the learning process for individuals who had reduced insulin sensitivity due to obesity.

Sleep loss is known to impact key processes such as attention, cognition, learning, memory, metabolism, and immune function.

Key study finding shows associations between the beat frequency in the rhythmic stimulus in the frontal left sites of infant brains and pathways related to brain modulation and nucleotide levels.

Advancements in the development of amyloid-targeting monoclonal antibodies show promise for treating Alzheimer disease, but there have been concerns around cost, adverse reactions, and inequity of care for marginalized patients.

Unexpectedly, the highest increases in delirium compared to projections were in the 66 to 74 years of age group, which could have important personal and societal repercussions, such as earlier development of dementia.

Adults aged 80 years and older and those living in areas with worse economic conditions are more likely to receive potentially inappropriate medications in the outpatient setting, which may be associated with cognitive impairment.

Nikhil Palekar discusses the FDA approval of lecanemab-irmb (Leqembi, Eisai) and what this means for those who have Alzheimer Disease.

Of the individuals that participated in the study, 65.3% reported hearing loss at 71 years and 96.2% reported hearing loss by 90 years.

The risk of death by suicide in soldiers was both directly and indirectly related to traumatic brain injury through confounding mental health diagnoses.

The study authors said that, to their knowledge, this will be the first systematic review focusing on the effects of cognitive interventions for those with chronic respiratory diseases.

Despite the improvements in the patients' symptoms, minor adverse effects including urinary urgency and liver-related issues were reported.