Brain Health

Comorbidities and cognitive impairment worsen non-adherence to anti-seizure medications in older adults.

A combination of cognitive behavioral therapy and medication had the most profound and stable result for patients suffering from insomnia.

Investigators suggest that a checklist completed by physicians and family members of individuals with severe acute brain injury may improve management needs.

Six weeks after infusion of GD2-CART01, 9 of 27 patients (33%) with relapsed or refractory high-risk neuroblastoma had a complete response or maintained a complete response.

The FDA considers alcohol hangover as a disease, requiring treatments to be registered as drugs.

Clinicians are often focused on reducing brain damage after traumatic injury, but considering nutrition is an important component to healing.

Pharmacists are uniquely positioned to interact with patients who may be seeking an OTC drug or supplement as first-line therapy for short sleep duration.

For chronic cases, encourage patients to seek medical care from their primary health care providers.

It is still unclear whether comorbidities have similar negative effects on cognition beyond those directly caused by obstructive sleep apnea.

Among those without HIV, the analyses found that respondents with a history of COVID-19 performed worse on processing speed than those who had never had COVID-19.

As more drugs gain coverage, decision-makers will need to more accurately diagnose Alzheimer disease, especially in the community setting.

Strong interprofessional team helps ensure safe transitions and minimize adverse events, medication errors

Perceived stress and cognitive performance are independently associated. Stress can also increase the risk of worsening cognition.

Eli Lilly treatment targets soluble amyloid beta and did not clear plaque or halt accumulation of amyloid in individuals treated with the drug in the A4 study.

The study clarifies why serotonin-based therapeutics, such as selective serotonin reuptake inhibitors, do not promote neuroplasticity in the same ways as psychedelics and other psychoplastogenic therapeutics.

Sodium oxybate is currently being studied for long-term safety and tolerability in the open label RESTORE clinical study in adults with narcolepsy.

Investigators noted medication prescription disparities among patients with dementia despite factoring for age and sex.

Vitamin D may reduce the risk of dementia because it clears amyloid that accumulates in the brain.

Cognitive performance was higher if a person maintained physical activity throughout their lifetime.

Investigators focus on whether legalization of the drug is associated with an increase in health care use for the psychotic disorder.

Low cognitive functioning and cognitive decline have been linked to an increased risk of morbidity and mortality.

The association with subgroups of gene variations based on expression or function should be assessed in larger studies, investigators say.

Early treatment of poor oral health could lead to brain health benefits.

Pimavanserin is an atypical antipsychotic indicated for the treatment of Parkinson disease-associated hallucinations and delusions.

Promising results for lecanemab's efficacy in patients with mild cognitive impairment or mild dementia associated with Alzheimer disease were accompanied by reports of adverse effects associated with treatment.

Pharmacists should be vigilant in recognizing medications that are causing insomnia in a patient's profile or electronic medical record.

When replaced with just 6 to 7 minutes daily of light-intensity exercise or sedentary behavior, data show poorer cognitive performance.

The findings suggest that reduced gray matter is not the cause of psychiatric illness, although it is found in regions of the brain associated with it.

The model can predict the chronological ages of cognitively normal participants with an average absolute error of 2.3 years, which is about 1 year more accurate than an existing model.

Study is the first to examine calciferol in brain tissue, which may help investigators understand dementia and its causes.