Ashley Gallagher, Associate Editor

Investigators said pre-exposure prophylaxis rollout is efficient in settings with high HIV incidence, but not in settings with low HIV incidence.

Due to the assessment of computerized tomography with criteria from 1999, the role of radiotherapy in patients with diffuse large B-cell lymphoma with bulky or extranodal disease remains undefined.

Patients with perinatally-acquired HIV reported low emotional, instrumental, and friendship support at 37%, 32%, and 36%, respectively.

A significant proportion of patients had negative hepatitis B surface antibody titers, indicating a need for vaccination to ensure protection for patients undergoing hemodialysis.

Findings indicate that the supplements improved white blood cell and platelet alterations while improving the inflammatory profile during high-intensity interval training.

Impact of healthy eating was especially evident in countries where consumption of these foods is low, which elevates the risk for cardiovascular disease, including heart attacks and strokes.

Population well-being was associated with cardiovascular disease morality and rates of conditions such as hypertension, diabetes, and obesity.

Despite an increase in HIV and poorer clinical outcomes among migrant populations, the uptake of PrEP among these individuals has been understudied.

Physically active individuals who had fewer than 6 hours of sleep showed faster cognitive decline overall.

Lecanemab-irmb is the first amyloid beta-directed antibody to be converted from an accelerated approval to a traditional approval for the treatment of Alzheimer disease.

In a study of individuals with Medicare, the incidence of type 2 diabetes was associated with approximately $30,000 to $98,000 excess lifetime medical expenditures.

Pirtobrutinib is a non–covalent (reversible) BTK inhibitor, demonstrating a 73.3% overall response rate with a median follow-up of 19.4 months among patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.

mRNA-1345 is a vaccine indicated for the prevention of respiratory syncytial virus-associated lower respiratory tract disease and acute respiratory disease.

Adalimumab-adaz HCF in the 100 mg/mL strength is approved for indications that are no longer covered exclusively for the reference Humira after July 2023.

All individuals with type 1 diabetes on the therapy had restored insulin secretion, improved glycemic control, improved time-in-range reduction, or elimination of exogenous insulin usage.

The prevalence of undiagnosed diabetes in earlier years in racial and ethnic minorities and lower education groups, leading to a decline in incidence over time.

Valoctocogene roxaparvovec-rvox (Roctavian; BioMarin) is a one-time gene therapy product administered as a single dose by intravenous infusion for hemophilia A.

Galcanezumab-gnlm (Emgality; Eli Lilly and Company) did not demonstrate superiority to rimegepant orally disintegrating tablet (Nurtec ODT) on the percentage of individuals achieving a 50% or greater reduction in monthly migraine headache days.

Somatrogon-ghla (Ngenla; Pfizer Inc, OPKO Health Inc) is a subcutaneous injection that is administered once weekly via a device allowing for titration based on patients’ needs.

Investigators call for further public awareness of other breast cancer risk factors, besides dense breasts, which could help identify more women who are at high risk.

Investigators found that the first biosimilar of trastuzumab, trastuzumab-anns (Kanjinti; Amgen), did maintain a strong and persistent advantage over the other 4 biosimilar entrants.

Investigators identified potential ways to inhibit the HpdBCA decarboxylase, which can reduce the production of p-cresol and make CDI more susceptible to bacteria in the gut microbiome.

Evidence shows vitamin D deficiency is linked to abnormal dopamine signaling disorders in neurodevelopment, including schizophrenia.

Memory killer cells have been shown to respond to immunotherapy, which is normally administered as a complement to other cancer treatments.

This approval makes ritlecitinib, in the 50 mg dosage, the first and only treatment approved by the FDA for adolescents aged 12 years and older with severe alopecia areata.

The results of the study were presented at the 83rd Scientific Sessions of the American Diabetes Association in San Diego, California and were also published in The Lancet.

Employees who did frequently use AI systems were more than likely to offer help to fellow employees, though it could have been a response to their loneliness.

As part of the approval condition, the FDA is requiring Sarepta Therapeutics to complete a clinical study to confirm the drug’s benefit in motor and physical functions.

The approval was based on data from 2 studies of blinatumomab in adults and pediatric patients with CD19-positive B-cell precursor acute lymphoblastic leukemia.

The Act4Biosimilars Action Plan highlights major challengers in preventing access to biosimilars and actionable steps to accelerate the adoption by overcoming these challenges.