Ashley Gallagher, Associate Editor

Expert discuss access barriers for the COVID-19, respiratory syncytial virus, and influenza vaccines, and ways to facilitate uptake.

Study findings indicated that many health care facilities are recovering from the COVID-19 pandemic and shortage of staff, which has caused door-to-balloon times to lag.

Investigators found that the adjusted mean change in A1C was –0.62% for dapagliflozin compared to 0.41% for a placebo in patients with type 2 diabetes.

mRNA-1083 (Moderna) was found comparable to the standard dose of Fluarix (GSK) in adults aged 50 to 64 years and Fluzone HD ( Sanofi) for influenza and Spikevax (Moderna) for COVID-19.

Hispanic individuals have been found to be more likely to develop complications as a result of diabetes compared to those who are non-Hispanic White.

White-coat hypertension was diagnosed in 17 of 35 patients who completed out-of-office blood pressure monitoring.

The new report includes actions to implement that could improve workplace conditions, which are the leading causes of high stress and occupational burnout across the pharmacy profession.

Diversity in patient populations, including age, race, ethnicity, and underrepresented regions, have increased in early-phase National Cancer Institute-sponsored trials.

The study investigators said that restricting access to direct-acting antiviral therapy due to alcohol consumption could create unnecessary barriers for those with hepatitis C virus.

Similarly, the results of a survey by the National Foundation for Infectious Diseases demonstrated that approximately 23% were worried about COVID-19 and 19% for respiratory syncytial virus.

Nedosiran (Rivfloza; Novo Nordisk Inc) injection is designed to inhibit the expression of liver enzyme lactate dehydrogenases leading to oxalate overproduction in patients 9 years of age and older with PH1.

Intravenous immunoglobulin could potentially be given throughout the duration of anti-BCMA bispecific antibody therapy for the treatment of multiple myeloma.

The MARIPOSA study evaluated amivantamab-vmjw (Rybrevant; Janssen Pharmaceutical) in combination with lazertinib compared to osimertinib and compared to lazertinib monotherapy in the first-line treatment of EGFR-mutated non–small cell lung cancer.

Investigators said that these results were promising, indicating that trigonelline could help to alleviate cognitive decline associated with aging.

The FDA has issued a Prescription Drug User Fee Act fate of March 26, 2024, for sotatercept (Merck) as treatment for adults with pulmonary arterial hypertension.

Investigators also found that rates of type 1 diabetes have been on the rise since 2016.

Lutetium Lu177 dotatate demonstrated significant and clinically meaningful progression-free survival for those with SSTR-positive and inoperable midgut neuroendocrine tumor.

Gepirone hydrochloride ER (Exxua; Fabre-Kramer Pharmaceuticals Inc) is in a new class of antidepressants, making it the first and only approved antidepressant that selectively targets serotonin 1A receptors.

Study findings showed a 10% increase in the proportion of individuals staying home due to COVID-19 policy restrictions being associated with a 0.27 increase in PHQ-9 scores for depression.

The National Community Pharmacists Association said the action was sent into motion by wrongful penalties for Medicare Part D prescriptions, called pharmacy direct and indirect remuneration fees.

Current federal statutes exclude anti-obesity medications for coverage when used for anorexia, weight loss, or weight gain.

Investigators reported that enfortumab vedotin-ejfv (Padcev; Astella Pharma Inc, Seagen Inc) in combination with pembrolizumab (Keytruda; Merck & Co Inc) met the dual primary endpoints of overall survival and progression-free survival in patients with previously untreated locally advanced or metastatic urothelial cancer.

Datopotamab deruxtecan (Dato-DXd; AstraZeneca, Daiichi Sankyo) also demonstrated improved overall survival compared to chemotherapy.

To promote positive mental health outcomes, researchers urge for policy interventions that focus on home connectedness, peer friendship, and school climate while avoiding full school closures.

Chemotherapy, medication for attention deficit/hyperactivity disorder, glucagon-like peptide-1 agonists for weight loss and diabetes, and local anesthetics were among the drugs most affected by shortages.

Empagliflozin (Jardiance) demonstrated a 28% relative risk reduction, with an absolute risk reduction of 3.6% per patient-year at risk in the treatment of chronic kidney disease.

Monoclonal antibody treatment resulted in suppression of HIV for more than 3 months, with some continuing to suppress the virus for more than 18 months after treatment stopped.

Standard amount of pre-workout should be taken at least 13.2 hours before bedtime to avoid sleep disruptions; however, there was no cut-off time for a cup of black tea.

Two separate study findings reported that a subset of dormant CD4+ cells could spontaneously produce HIV RNA and proteins, impacting a patient’s HIV-specific immune responses.

The sNDA is based on data that evaluated belzutifan (Welireg; Merck) compared to everolimus (Afinitor; Novartis) for the treatment of advanced renal cell carcinoma.