Lactate Is a Key Regulator of Immune Escape, Bone Marrow Fibrosis in Myelofibrosis
February 11th 2025Circulating lactate is increased in patients with myelofibrosis and corresponds with the remodeling of lactate export channel monocarboxylate transporter 4, suggesting a link with fibrosis establishment.
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Novel Molecular Imaging Agent for Detection of Bowel Inflammation in Crohn Disease Receives FDA FTD
February 10th 2025BR55, an injection of perfluorobutane/nitrogen lipopeptide-coated microbubbles, could aid in the detection of angiogenesis and allow for earlier diagnosis in patients with Crohn disease.
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Zahra Mahmoudjafari, PharmD, BCOP, FHOPA, discusses the logistical challenges and interprofessional strategies essential for delivering cellular therapies in outpatient settings, emphasizing the pharmacist's role in improving patient outcomes and addressing health disparities.
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Pharmacists Play Pivotal Roles in Outpatient CAR T-Cell Therapy
February 9th 2025Molly Schiffer, PharmD, BCOP, discusses the logistical and operational challenges of delivering outpatient CAR T-cell therapy, emphasizing the benefits of outpatient treatment, including reduced costs, improved access to therapy, and better quality of life for patients.
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Genetic Diversity in African Populations Can Advance Precision Medicine Globally
February 8th 2025Africa's unparalleled genetic diversity presents both a challenge and an opportunity to advance precision medicine, with a focus on leveraging pharmacogenetics to improve drug efficacy and reduce adverse reactions.
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Unveiling the Dark Genome: Targeting Stress-Activated Base Editors to Halt Cancer Progression
February 7th 2025Catriona Jamieson, MD, PhD, discusses the role of stress-activated base editors like ADAR1p150 and APOBEC enzymes in cancer progression and highlights innovative approaches to halt these processes and improve therapeutic outcomes.
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