Pharmacy Clinical Pearl of the Day: Factor V Leiden

Clinical Pearl of the Day: Factor V Leiden

Factor V Leiden is a mutation of one of the clotting factors in the blood.

Insight:

• This mutation can increase the chance of developing abnormal blood clots, most commonly in the legs or lungs.
• Most people with factor V Leiden never develop abnormal clots. But in those who do, these abnormal clots can lead to long-term health problems or become life-threatening.
• Both men and women can have factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen.
• Symptoms may include pain, swelling, redness, and warmth.
• Risk factors may include having 2 faulty genes, immobility, taking estrogens, and in patients with blood types A, B, or AB.
• Treatment may include a short course of blood thinners, leg wraps that inflate and deflate to keep blood moving in your legs, compression stockings, and going for walks soon after surgery.
• These patients should avoid sports with too much contact, use a soft toothbrush, and be cautious with household tasks.

Sources:

Factor V Leiden - Symptoms and causes - Mayo Clinic

factor v leiden - Google Search