Indication: Xeljanz can be used for rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and polyarticular course juvenile idiopathic arthritis.

Insight:

Dosing: Xeljanz 5 mg twice daily or Xeljanz XR 11 mg once daily up to 22 mg per day.
- Dosage form:
  - Xeljanz tablets: 5 mg, 10 mg
  - Xeljanz XR Tablets: 11 mg, 22 mg
  - Xeljanz oral solution: 1 mg/mL
Adverse events (AEs): Most common AEs are upper respiratory tract infection, nasopharyngitis, diarrhea, headache, and herpes zoster.
Mechanism of action: Xeljanz is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes that transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function.
Manufacturer: Pfizer

Sources:

Homepage (xeljanzhcp.com)
xeljanz - Google Search