Article

Daily Medication Pearl: Aripiprazole Lauroxil (Aristada)

Aripiprazole Lauroxil (Aristada) is a long-acting injectable atypical antipsychotic for the treatment of schizophrenia in adults.

Medication Pearl of the Day: Aripiprazole Lauroxil (Aristada)

Indication: Aripiprazole Lauroxil(Aristada) is a long-acting injectable atypical antipsychotic indicated for the treatment of schizophrenia in adults.

Insight:

  • Dosing: Administer aripiprazole lauroxil by intramuscular injection in the deltoid (441 mg dose only) or gluteal (441 mg, 662 mg, 882 mg or 1064 mg) muscle by a health care professional.
  • Dosage forms: Extended-release injectable suspension 441 mg, 662 mg, 882 mg, or 1064 mg single-dose pre-filled syringe.
  • Adverse events: The most frequently observed adverse reaction with aripiprazole lauroxil (incidence ≥5% and at least twice that for placebo) was akathisia.
  • Mechanism of action: Aripiprazole lauroxil is a prodrug of aripiprazole. Following intramuscular injection, aripiprazole lauroxil is likely converted by enzyme-mediated hydrolysis to N-hydroxymethyl aripiprazole, which is then hydrolyzed to aripiprazole. The mechanism of action of aripiprazole in schizophrenia is unknown. However, efficacy could be mediated through a combination of partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at 5-HT2A receptors.
  • Manufacturer: Alkermes

Reference

ARISTADA® Prescribing Information (aristadahcp.com)

Newsletter

Stay informed on drug updates, treatment guidelines, and pharmacy practice trends—subscribe to Pharmacy Times for weekly clinical insights.

Related Videos
Inflammation concept, inflammated human tissues 3d rendering - Image credit: picture-waterfall | stock.adobe.com