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Opinion|Videos|February 27, 2025

Beyond HER2: Expanding the Biomarker Testing Landscape in Metastatic Breast Cancer

Panelists discuss how HER2 testing optimization requires multisite sampling and quantitative assessment methods to account for intratumoral heterogeneity. Beyond HER2, biomarkers such as PI3K mutations, hormone receptor status, and tumor mutational burden can guide therapy selection for metastatic breast cancer (mBC), enabling more personalized treatment approaches.

Episodes in this series

Video content above has been prompted by the following:

  • How can we optimize HER2 testing and antibody-drug conjugate treatment selection considering tumor heterogeneity across different cancer sites?
  • Are there additional biomarkers beyond HER2 that can help guide mBC therapy selection?

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