Memorial Sloan Kettering Cancer Center | Strategic Alliance Partners

Alison Moskowitz, MD, discusses the clinical considerations, dosing strategies, and the critical role of pharmacists in managing toxicities and tailoring treatment plans for dual-targeted therapy with ruxolitinib and duvelisib.

Komal Jhaveri MD, FACP, shares that the combination of imlunestrant plus abemaciclib further improved progression-free survival compared to imlunestrant alone.

Treatment often involves a combination of preventive measures, topical therapies, and systemic treatments.

The drug's safety profile included significant rates of nausea, vomiting, and hematologic toxicities like neutropenia and thrombocytopenia. Although promising, brigimadlin requires careful management of adverse effects, including antiemetic and hematologic support.

Current guidelines recommend a backbone of SLGT2 therapy in patients with HFpEF who have no contraindications.

Currently, standard first-line chemotherapy with or without immunotherapy for patients with non-small-cell lung cancer (NSCLC) with HER2 mutations has limited efficacy.

The CEPHEUS trial also highlights the importance of minimal residual disease (MRD) as a study end point.

IMROZ study data show Isa-VRd may be a new standard of care.