Aislinn Antrim, MA, Assistant Managing Editor

The company received Fast Track designation from the FDA for GEN-1, a DNA-mediated interleukin-12 (IL-12) immunotherapy.

Investigators found a statistically significant improvement in both overall survival and progression-free survival for patients who received pembrolizumab with chemotherapy.

Intranasal administration of virucidal and antiviral therapies may provide added clinical benefit by decreasing viral activity in the nasal pathway, preventing COVID-19 transmission and managing disease severity.

The independent data safety monitoring board conducted a specific review of thrombotic events related to AstraZeneca’s COVID-19 vaccine and found no increased risk.

Nine in 10 patients with multiple sclerosis who received the medication did not have worsening of 3-month disability, and ponesimod showed a numerical benefit in delaying disability progression.

Study findings contradict a long-standing hypothesis that held the pancreas increases insulin production because the cells have already become insulin-resistant and blood sugar rises as a result.

Language barriers can present a major obstacle to patient involvement in cancer care, although clinicians recommended several potential strategies to help patients who speak different languages.

The study results reiterate the importance of interventions to lower prescribing rates of potentially inappropriate drugs among older adults.

Health care professionals should address potential barriers to completing the COVID-19 vaccination series, including scheduling second-dose appointments at the first-dose administration and sending reminders for second-dose visits.

The approach inverts missing alleles into an immune cell activating signal, which engineered T cells can then attack and destroy.

With a wide array of cannabidiol (CBD) and CBD extract products available without a prescription, pharmacists have an increasingly important role to play in counseling patients on which products may work for them and how they should be properly used.

Adverse effects, such as strange dreams, insomnia, and sleep disorders may be more likely for patients with a history of cardiovascular health issues.

Although COVID-19 tests fell by 10% during the past week, positive cases fell by a significant 12%, resulting in the ninth consecutive week of a declining national positivity rate.

With a 1-hour infusion and lower infusion volume, oritavancin could minimize health system costs to treat these infections and improve efficiency in clinical practice.

Some HIV antibody variants, which had mutations concentrated in antibody framework regions, achieved up to 37% neutralization breadth compared to 28% neutralization in the unmodified antibody.

In addition to prevention with a live attenuated vaccine, treatment options for herpes zoster can include antivirals or symptom management with corticosteroids or analgesics.

There have been 15 events of deep vein thrombosis and 22 events of pulmonary embolism reported across the European Union and United Kingdom.

Sodas have significantly high sugar levels and a lack of nutritional value, which may contribute to conditions that can lead to breast cancer.

Findings show that an inflamed environment allows clostridioides difficile to thrive in an environment that is inhospitable to competing bacteria.

Bristol Myers Squibb and bluebird bio are seeking FDA approval for ide-cel as a standard therapy for relapsed myeloma, with a decision expected by the end of March.

The investigators observed a near normal age distribution among patients with long-term COVID-19 symptoms, including children.

Compared to the placebo group, patients with diabetes who received a 54-week course of treatment had higher levels of endogenous insulin secretion with no identified safety concerns.

The oral, next-generation vascular endothelial growth factor tyrosine kinase inhibitor is the first therapy approved for this patient population following 2 or more prior systemic therapies.

Study finds cancer survivors were 42% more likely to report walking at the slowest pace and had a 24% greater risk of mobility disability compared to individuals who never had cancer.

The change in guidelines address how to assess damage to the kidneys caused by fluid loss associated with severe C. diff infection.

The potential for some people to skip the second COVID-19 vaccine dose may make more doses available to others.

The additional COVID-19 doses will provide a buffer in addition to the already procured vaccines, and will also allow experts to plan for the later part of 2021, according to a White House briefing.

When applied as a filler for soft tissue defects and voids, the regenerative tissue filler shows promise for accelerating and improving tissue restoration outcomes.

Notably, the United States has now administered the most first-shot COVID-19 vaccinations of any country, with 82.6 million.

The guidance said relaxing certain measures for vaccinated individuals may help improve COVID-19 vaccine acceptance and uptake.