Daily Medication Pearl: Privigen Immune Globulin Intravenous (Human)

Medication Pearl of the Day: Privigen Immune Globulin Intravenous (Human)

Indication: Privigen is an immune globulin intravenous (human), 10% liquid indicated for the treatment of primary humoral immunodeficiency, chronic immune thrombocytopenic purpura in patients 15 years of age and older, chronic inflammatory demyelinating polyneuropathy in adults.

Insight:

• Dosing: Dosing may vary from 0.5 mg/kg/min to 8 mg/kg/min
• Dosage forms: Privigen is a liquid solution containing 10% IgG (0.1 g/mL).
• Adverse events: The most common adverse reactions, observed in >5% of study subjects, were headache, fatigue, nausea, chills, vomiting, back pain, pain, elevated body temperature, abdominal pain, diarrhea, cough, stomach discomfort, chest pain, joint swelling/effusion, influenza-like illness, pharyngolaryngeal pain, urticaria, and dizziness. Serious adverse reactions were hypersensitivity, chills, fatigue, dizziness, and increased body temperature.
• Mechanism of action: Privigen supplies a broad spectrum of opsonizing and neutralizing IgG antibodies against a wide variety of bacterial and viral agents. The mechanism of action has not been fully elucidated but may include immunomodulatory effects.

Source: Privigen-Prescribing-Information.pdf (llnwd.net)