Combination Shows Promise for Treating Advanced Non Small Cell Lung Cancer

Combining pegilodecakin (AM0010) with nivolumab (Opdivo) or pembrolizumab (Keytruda) induced an overall response rate (ORR) of 41% in patients with advanced non—small cell lung cancer (NSCLC), according to findings from an early phase study presented at the 2018 ASCO Annual meeting.

At a median follow-up of 24.7 months (range, 9.1-39.1), partial responses were observed in 11 of 27 evaluable patients who received pegilodecakin plus a PD-1 inhibitor. An additional 12 patients had stable disease.

The median overall survival (OS) was 32.2 months in the patients who received pegilodecakin/pembrolizumab and the median progression-free survival (PFS) was 11 months. The median OS and PFS have not yet been reached for the cohort of patients receiving pegilodecakin plus nivolumab.

“Pegilodecakin when added to anti—PD-1 therapy in advanced NSCLC patients was associated with response rates, and durability of benefit greater than has been seen with anti–PD-1 alone,” lead investigator Edward B. Garon, MD, director of Thoracic Oncology at the Jonsson Comprehensive Cancer Center at University of California, Los Angeles, wrote in their poster.

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