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Q:What is the procedure for sucralfate rectal retentionsuspension?

A:Sucralfate in an acid medium (gastric contents) formsa complex with protein that can coat gastric mucosa,especially ulcer sites. It has been used topically to aid healing ofvenous stasis ulcers and in the treatment of bleeding skin ulcersof malignancy. It has been administered rectally as a slurry inthe treatment of distal colitis. Some absorption of aluminumcan occur: sucralfate should be used with caution in patientswith renal impairment. Amounts administered varied amongthe studies from 2 to 6 g.

Procedure:

1.Weigh and/or measure the ingredients accurately.

2. Place 8 sucralfate tablets in a 120-mL glass Rx bottle.

3. Add 40.00 mL of purified (distilled) water to the bottlein Step 2, and allow it to stand for about 2 min.

4. Add 40.00 mL of sorbitol 70% and shake well.

5. Flavoring may be added to this preparation, if the flavoringdoes not contain acids or suspending agents.*

6. Add sufficient purified (distilled) water to the suspensionin Step 4 to bring the volume of the preparationto 120 mL (use a graduated cylinder for this step).

7. Label: "Shake Well" and "Refrigerate" (no preservativeis included in this preparation). Counsel thepatient to remove the preparation or the amount tobe administered from the refrigerator at least 1/2 hrbefore administration to allow it to come to roomtemperature.

Mr. Erickson is director of professional affairs at Gallipot Inc.

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