Navigating the New Era of Primary Biliary Cholangitis Treatments

Ryan Haumschild, PharmD, MS, MBA, CPEL; Sandy Sallam, PharmD, BCACP, CDCES; and Aparna Goel, MD, examine the evolving landscape of primary biliary cholangitis management, from initial diagnosis through first-line ursodeoxycholic acid therapy to emerging second-line treatments including seladelpar, elafibranor, and obeticholic acid, with particular focus on efficacy data, safety profiles, treatment transitions, and strategies for optimizing patient outcomes while navigating regulatory and access challenges.