Daily Medication Pearl: Brimonidine Tartrate/Timolol (Combigan)

Medication Pearl of the Day: Brimonidine tartrate/timolol (Combigan)

Indication: Brimonidine tartrate/timolol (Combigan) is an alpha-adrenergic receptor agonist with a beta-adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.

Insight:

• Dosing: One drop in the affected eye(s), twice daily approximately 12 hours apart.
• Dosage forms: Solution containing 2 mg/mL brimonidine tartrate and 5 mg/mL timolol.
• Adverse events: Most common adverse reactions occurring in approximately 5% to 15% of patients include allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, and stinging
• Mechanism of action: Combigan is comprised of 2 components: brimonidine tartrate and timolol. Each of these components decreases elevated intraocular pressure, whether or not associated with glaucoma.
• Manufacturer: Allergan

Sources:

• 20151015-Combigan-USPI-72060US15.pdf (allergan.com)
• combigan image - Google Search