Gastrointestinal Health

The designation was granted after positive results from the phase 1 STOMP-I clinical trial (NCT01915927).

The authors are optimistic that this method can be replicated to identify other allergens that manifest into eosinophilic esophagitis (EoE).

BR55, an injection of perfluorobutane/nitrogen lipopeptide-coated microbubbles, could aid in the detection of angiogenesis and allow for earlier diagnosis in patients with Crohn disease.

For pharmacists wondering whether bismuth quadruple therapy still reigns as the gold standard, the wait is over—the latest recommendations are here.

The model also predicted prevalent cases of decompensated cirrhosis would more than triple, incident liver cancer cases would nearly double, and transplant almost quadruple.

Lu-edotreotide (ITM-11; ITM) met its primary endpoint of prolonging progression-free survival (PFS).

The authors note that this may cause disruptions in the metabolic stability of lipid processing and storage, impacting the liver and accelerating damaging adaptative responses.

Biosimilar use is not linked to an increased risk of treatment failure among pediatric patients with inflammatory bowel disease (IBD).

Recommendations help influence the rate of gastric emptying, improve compliance, and prevent interruption of weight loss for patients.

This is mirikizumab’s second FDA-approved indication in inflammatory bowel disease.

The tablets are indicated for treatment of adults with chronic idiopathic constipation, with further research needed to assess efficacy and safety in children.

Adherence to thiopurine medications after 6 months of use was 87.9% under direct pharmacist care but 65.7% under general practitioner guidance.

Ustekinumab-stba (Steqeyma; Celltrion) is a subcutaneous treatment for adult and pediatric patients with plaque psoriasis arthritis, psoriatic arthritis, Crohn disease, and ulcerative colitis.

The risk of therapy duplication with OTC and prescription PPIs can be lowered with an innovative, multi-faceted, and intentional approach by pharmacy teams and prescribers.

The primary end point of clinical remission at week 26 was met, with 36.7% of individuals treated with RHB-104 achieving clinical remission.

An analysis of interaction checkers and product summaries revealed large differences in the consistency and reliability of providing accurate information on potential drug-drug interactions.

Study shows that orange peel extract may reduce risk of heart disease and adverse cardiovascular events.

The primary endpoint of the study was clinical remission at week 52 with vedolizumab

Melatonin is linked to circadian rhythm, mitochondrial function, and neuroinflammation.

Individuals included in the study reported positive changes in fatigue, and disease activity displayed endoscopic and histologic remission.

Children with normal weight had different community relationships compared to children with overweight or obesity.

Repairing the intestinal epithelial barrier is paramount in the treatment of IBD.

Nearly 60% of patients who regained all the weight stayed in remission at 5 years post-surgery, according to study results.

The approval of irinotecan liposome offers an improved first-line treatment option for individuals diagnosed with metastatic pancreatic adenocarcinoma.

Researchers will continue to research how lantibiotic’s antimicrobial effects can be harnessed for good.

The designation offers support in developing potential new medicines, treatment, and diagnosis to prevent rare conditions, like EoE.

Radioligands may be able to deliver radiation to advanced tumor cells anywhere in the body.

There may be a pathophysiological basis for therapy relating to the to the gut-liver axis.